Restriction of Human Immunodeficiency Virus Type 1 by TRIM-CypA Occurs with Rapid Kinetics and Independently of Cytoplasmic Bodies, Ubiquitin, and Proteasome Activity

TRIM-CypA is an owl monkey-specific variant of the retrovirus restriction factor TRIM5α. Here, we exploit its modular domain organization and cyclosporine sensitivity to probe the kinetics and mechanism of TRIM5-mediated restriction. Time of addition/withdrawal experiments reveal that inhibition of...

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Bibliographic Details
Main Authors: Perez-Caballero, David, Hatziioannou, Theodora, Zhang, Fengwen, Cowan, Simone, Bieniasz, Paul D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316013/
https://ncbi.nlm.nih.gov/pubmed/16306627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15567-15572.2005
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