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Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs

In C. elegans, insulin signaling affects development, lifespan and stress resistance. Several studies have shown that insulin signaling affects lifespan in an endocrine-like manner from different cells, while the major downstream target of insulin, the FOXO transcription factor encoded by daf-16, ma...

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Main Authors: Iser, Wendy B., Gami, Minaxi S., Wolkow, Catherine A.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262836/
https://ncbi.nlm.nih.gov/pubmed/17257591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2006.04.467
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