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Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation
Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains with Alzheimer’s disease. The phosphorylation sites of tau are mainly localized in the proline-rich (residues 172–251) and C-terminal tail (residues 368–441) regions, which flan...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2262108/ https://ncbi.nlm.nih.gov/pubmed/18052981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2007.05955.x |
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