Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains with Alzheimer’s disease. The phosphorylation sites of tau are mainly localized in the proline-rich (residues 172–251) and C-terminal tail (residues 368–441) regions, which flan...

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Bibliographic Details
Main Authors:	Liu, Fei, Li, Bin, Tung, E-Jan, Grundke-Iqbal, Inge, Iqbal, Khalid, Gong, Cheng-Xin
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2262108/ https://ncbi.nlm.nih.gov/pubmed/18052981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2007.05955.x
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Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

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