Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain

BACKGROUND AND PURPOSE: The analgesics, paracetamol and dipyrone are weak inhibitors of the cyclooxygenase isoforms 1 or 2 (COX-1, COX-2) but more potent on COX-3. Both are also weak anti-inflammatory agents, relative to their analgesic and antipyretic activities. In a model of inflammatory pain med...

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Bibliografiske detaljer
Main Authors: Rezende, R M, França, D S, Menezes, G B, dos Reis, W G P, Bakhle, Y S, Francischi, J N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259218/
https://ncbi.nlm.nih.gov/pubmed/18157167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707630
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