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Dual effects of Rho-kinase inhibitors on a rat model of inflammatory pain

BACKGROUND: Rho-kinases (ROCKs), a family of small GTP-dependent enzymes, are involved in a range of pain models, and their inhibition typically leads to antinociceptive effects. OBJECTIVES: To study the effects of inhibiting ROCKs using two known inhibitors, Y27632 and HA1077 (fasudil), administere...

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Detalhes bibliográficos
Publicado no:Pain Res Manag
Main Authors: Paiva-Lima, Patricia, Bakhle, YS, Francischi, Janetti N
Formato: Artigo
Idioma:Inglês
Publicado em: Pulsus Group Inc 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273717/
https://ncbi.nlm.nih.gov/pubmed/24992453
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