Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

Diabetic kidney disease is associated with monocyte chemoattractant CC chemokine ligand 2 (CCL2)-dependent glomerular and interstitial macrophage recruitment. In addition, nephropathy is delayed in Ccl2 mutant diabetic mice. However, whether the late onset of therapeutic Ccl2 blockade modulates the...

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Detalhes bibliográficos
Main Authors: Ninichuk, Volha, Clauss, Sebastian, Kulkarni, Onkar, Schmid, Holger, Segerer, Stephan, Radomska, Ewa, Eulberg, Dirk, Buchner, Klaus, Selve, Norma, Klussmann, Sven, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258250/
https://ncbi.nlm.nih.gov/pubmed/18258851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070601
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