Presenilin-1 280Glu→Ala Mutation Alters C-Terminal APP Processing Yielding Longer Aβ Peptides: Implications for Alzheimer’s Disease

Presenilin (PS) mutations enhance the production of the Aβ42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Aβ42 species is preferentially produced has not been elucidated, nor is the mechanism by which PS mutations produce early-onset dementia establis...

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Detaylı Bibliyografya
Asıl Yazarlar: Van Vickle, Gregory D, Esh, Chera L, Kokjohn, Tyler A, Patton, R Lyle, Kalback, Walter M, Luehrs, Dean C, Beach, Thomas G, Newel, Amanda J, Lopera, Francisco, Ghetti, Bernardino, Vidal, Ruben, Castaño, Eduardo M, Roher, Alex E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: ScholarOne 2008
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258166/
https://ncbi.nlm.nih.gov/pubmed/18317569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2007-00094.VanVickle
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