Presenilin-1 280Glu→Ala Mutation Alters C-Terminal APP Processing Yielding Longer Aβ Peptides: Implications for Alzheimer’s Disease

Presenilin (PS) mutations enhance the production of the Aβ42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Aβ42 species is preferentially produced has not been elucidated, nor is the mechanism by which PS mutations produce early-onset dementia establis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Van Vickle, Gregory D, Esh, Chera L, Kokjohn, Tyler A, Patton, R Lyle, Kalback, Walter M, Luehrs, Dean C, Beach, Thomas G, Newel, Amanda J, Lopera, Francisco, Ghetti, Bernardino, Vidal, Ruben, Castaño, Eduardo M, Roher, Alex E
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258166/
https://ncbi.nlm.nih.gov/pubmed/18317569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2007-00094.VanVickle
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados