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Synthesis and Biological Activity of Phosphatidylinositol 3, 4, 5-Trisphosphorothioate
Metabolically-stabilized analogues of PtdIns(3,4,5)P(3) have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analogue of PtdIns(3,4,5)P(3). Intracellular deliv...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2255567/ https://ncbi.nlm.nih.gov/pubmed/18060773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.041 |
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