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Activated protein C–cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
Activated protein C (APC) signals in endothelial cells ex vivo through protease activated receptor-1 (PAR1). However, it is controversial whether PAR1 can mediate APC's protective effects in sepsis because the inflammatory response results in thrombin generation and thrombin proteolytically act...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2254534/ https://ncbi.nlm.nih.gov/pubmed/18089851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-113076 |
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