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Application of structural-dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-α converting enzyme (TACE)

Zinc dependent metalloproteinases comprise a large family of structurally homologous enzymes with a wide variety of biological roles. Originally described as proteinases involved in extracellular matrix (ECM) catabolism, these enzymes were later found to serve major roles as initiators of signaling...

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Détails bibliographiques
Auteurs principaux: Sagi, Irit, Milla, Marcos E.
Format: Artigo
Langue:Inglês
Publié: 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254313/
https://ncbi.nlm.nih.gov/pubmed/17963710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.07.037
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