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A critical assessment of the topomer search model of protein folding using a continuum explicit-chain model with extensive conformational sampling

Recently, a series of closely related theoretical constructs termed the “topomer search model” (TSM) has been proposed for the folding mechanism of small, single-domain proteins. A basic assumption of the proposed scenarios is that the rate-limiting step in folding is an essentially unbiased, diffus...

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Главные авторы: Wallin, Stefan, Chan, Hue Sun
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253387/
https://ncbi.nlm.nih.gov/pubmed/15930009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041317705
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