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The topomer-sampling model of protein folding

Clearly, a protein cannot sample all of its conformations (e.g., ≈3(100) ≈ 10(48) for a 100 residue protein) on an in vivo folding timescale (<1 s). To investigate how the conformational dynamics of a protein can accommodate subsecond folding time scales, we introduce the concept of the native to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Debe, Derek A., Carlson, Matt J., Goddard, William A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 1999
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC15813/
https://ncbi.nlm.nih.gov/pubmed/10077555
Tagiau: Ychwanegu Tag
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