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Nonglassy kinetics in the folding of a simple single-domain protein

Theory suggests that the otherwise rapid folding of simple heteropolymer models becomes “glassy”—dominated by multiple kinetically trapped misfolded states—at low temperatures or when the overall bias toward the native state is reduced relative to the depth of local minima. Experimental observations...

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Autori principali: Gillespie, Blake, Plaxco, Kevin W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC17286/
https://ncbi.nlm.nih.gov/pubmed/11050233
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