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The topomer search model: A simple, quantitative theory of two-state protein folding kinetics

Most small, single-domain proteins fold with the uncomplicated, single-exponential kinetics expected for diffusion on a smooth energy landscape. Despite this energetic smoothness, the folding rates of these two-state proteins span a remarkable million-fold range. Here, we review the evidence in favo...

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Detalhes bibliográficos
Main Authors: Makarov, Dmitrii E., Plaxco, Kevin W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312397/
https://ncbi.nlm.nih.gov/pubmed/12493824
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