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A critical assessment of the topomer search model of protein folding using a continuum explicit-chain model with extensive conformational sampling
Recently, a series of closely related theoretical constructs termed the “topomer search model” (TSM) has been proposed for the folding mechanism of small, single-domain proteins. A basic assumption of the proposed scenarios is that the rate-limiting step in folding is an essentially unbiased, diffus...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253387/ https://ncbi.nlm.nih.gov/pubmed/15930009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041317705 |
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