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Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

The reliable identification of β-aggregating stretches in protein sequences is essential for the development of therapeutic agents for Alzheimer’s and Parkinson’s diseases, as well as other pathological conditions associated with protein deposition. Here, a model based on physicochemical properties...

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Detalhes bibliográficos
Main Authors: Tartaglia, Gian Gaetano, Cavalli, Andrea, Pellarin, Riccardo, Caflisch, Amedeo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253302/
https://ncbi.nlm.nih.gov/pubmed/16195556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051471205
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