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Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrP(Sc) from sporadic Creutzfeldt-Jakob Disease
In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice. These studies showed that unlike “classical” PrP(Sc) produced in vivo, the amyloid fibrils generated in vitro were more pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253268/ https://ncbi.nlm.nih.gov/pubmed/15802644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041186605 |
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