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Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrP(Sc) from sporadic Creutzfeldt-Jakob Disease

In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice. These studies showed that unlike “classical” PrP(Sc) produced in vivo, the amyloid fibrils generated in vitro were more pro...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Bocharova, Olga V., Breydo, Leonid, Salnikov, Vadim V., Gill, Andrew C., Baskakov, Ilia V.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Cold Spring Harbor Laboratory Press 2005
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253268/
https://ncbi.nlm.nih.gov/pubmed/15802644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041186605
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