Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila

Aggregation of the amyloid-β-42 (Aβ42) peptide in the brain parenchyma is a pathological hallmark of Alzheimer's disease (AD), and the prevention of Aβ aggregation has been proposed as a therapeutic intervention in AD. However, recent reports indicate that Aβ can form several different prefibri...

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Bibliografiska uppgifter
Huvudupphovsmän: Iijima, Koichi, Chiang, Hsueh-Cheng, Hearn, Stephen A., Hakker, Inessa, Gatt, Anthony, Shenton, Christopher, Granger, Linda, Leung, Amy, Iijima-Ando, Kanae, Zhong, Yi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2250771/
https://ncbi.nlm.nih.gov/pubmed/18301778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001703
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