Overexpression of Neprilysin Reduces Alzheimer Amyloid-β42 (Aβ42)-induced Neuron Loss and Intraneuronal Aβ42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila

The amyloid-β42 (Aβ42) peptide has been suggested to play a causative role in Alzheimer disease (AD). Neprilysin (NEP) is one of the rate-limiting Aβ-degrading enzymes, and its enhancement ameliorates extracellular amyloid pathology, synaptic dysfunction, and memory defects in mouse models of Aβ amy...

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Main Authors: Iijima-Ando, Kanae, Hearn, Stephen A., Granger, Linda, Shenton, Christopher, Gatt, Anthony, Chiang, Hsueh-Cheng, Hakker, Inessa, Zhong, Yi, Iijima, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441542/
https://ncbi.nlm.nih.gov/pubmed/18463098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710509200
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