Herpes Simplex Virus Type 1 DNA Is Immunostimulatory In Vitro and In Vivo

Recently, prokaryotic DNAs containing unmethylated CpG motifs have been shown to be intrinsically immunostimulatory both in vitro and in vivo, tending to promote Th1-like responses. In contrast, CpG dinucleotides in mammalian DNAs are extensively methylated on cytosines and hence immunologically ine...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lundberg, Patric, Welander, Paula, Han, Xiao, Cantin, Edouard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC225007/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14512563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.20.11158-11169.2003
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