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Cooperative hydrogen bond interactions in the streptavidin–biotin system
The thermodynamic and structural cooperativity between the Ser45– and D128–biotin hydrogen bonds was measured by calorimetric and X-ray crystallographic studies of the S45A/D128A double mutant of streptavidin. The double mutant exhibits a binding affinity ~2 × 10(7) times lower than that of wild-typ...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2249767/ https://ncbi.nlm.nih.gov/pubmed/16452627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051970306 |
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