Mapping the phase diagram of the writhe of DNA nanocircles using atomistic molecular dynamics simulations

We have investigated the effects of duplex length, sequence, salt concentration and superhelical density on the conformation of DNA nanocircles containing up to 178 base pairs using atomistic molecular dynamics simulation. These calculations reveal that the partitioning of twist and writhe is govern...

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Detalles Bibliográficos
Main Authors: Harris, Sarah A., Laughton, Charles A., Liverpool, Tanniemola B.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
Assuntos:
Computational Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248748/
https://ncbi.nlm.nih.gov/pubmed/17984075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm891
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