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SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy
BRCA1, a tumor suppressor gene, is implicated in the repression and activation of transcription via interactions with a diverse range of proteins. The mechanisms regulating the action of BRCA1 are not fully understood. Here, we use the promoters of Gadd45α, p27(KIP1) and p21(WAF1/CIP1) to demonstrat...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2248730/ https://ncbi.nlm.nih.gov/pubmed/18025037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm969 |
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