BRCA1 is a negative modulator of the PRC2 complex

The Polycomb-repressive complex 2 (PRC2) is important for maintenance of stem cell pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 trimethylation (H3K27me3) and transcriptional repression of differentiation genes. Here we show that the tumour-suppressor protein...

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Detalhes bibliográficos
Main Authors: Wang, Lan, Zeng, Xianzhuo, Chen, Shuai, Ding, Liya, Zhong, Jian, Zhao, Jonathan C, Wang, Liguo, Sarver, Aaron, Koller, Antonius, Zhi, Jizu, Ma, Yupo, Yu, Jindan, Chen, Junjie, Huang, Haojie
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671259/
https://ncbi.nlm.nih.gov/pubmed/23624935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.95
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