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Conformational pH dependence of intermediate states during oligomerization of the human prion protein
Intermediate states are key to understanding the molecular mechanisms governing protein misfolding. The human prion protein (PrP) can follow various misfolding pathways, and forms a soluble β-sheet-rich oligomer under acidic, mildly denaturing, high salt conditions. Here we describe a fast conformat...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2248315/ https://ncbi.nlm.nih.gov/pubmed/18218718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073163308 |
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