Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

mRNA surveillance pathways selectively clear defective mRNAs from the cell. As such, these pathways serve as important modifiers of genetic disorders. Nonsense-mediated decay (NMD), the most intensively studied surveillance pathway, recognizes mRNAs with premature termination codons (PTCs). In mamma...

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Hlavní autoři: Silva, Ana Luísa, Ribeiro, Patrícia, Inácio, Ângela, Liebhaber, Stephen A., Romão, Luísa
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248256/
https://ncbi.nlm.nih.gov/pubmed/18230761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.815108
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