Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae

The Nonsense-Mediated mRNA Decay (NMD) pathway mediates the rapid degradation of mRNAs that contain premature stop mutations in eukaryotic organisms. It was recently shown that mutations in three yeast genes that encode proteins involved in the NMD process, UPF1, UPF2, and UPF3, also reduce the effi...

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Main Authors: KEELING, KIM M., LANIER, JESSICA, DU, MING, SALAS-MARCO, JOE, GAO, LIN, KAENJAK-ANGELETTI, ANISA, BEDWELL, DAVID M.
格式: Artigo
語言:Inglês
出版: Copyright 2004 by RNA Society 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262634/
https://ncbi.nlm.nih.gov/pubmed/15037778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5147804
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