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The C terminus of β-tubulin regulates vinblastine-induced tubulin polymerization

Oligoanions such as sodium triphosphate or GTP prevent and/or reverse vinblastine-induced polymerization of tubulin. We now show that the anions of glutamate-rich extreme C termini of tubulin are similarly involved in the regulation of the vinblastine effect. Cleavage of the C termini by limited pro...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rai, Sadananda S., Wolff, J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22475/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9539723/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.8.4253
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