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Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

Recent evidence suggests that the ability of ceramides to induce apoptosis is due to a direct action on mitochondria. Mitochondria are known to contain enzymes responsible for ceramide synthesis and hydrolysis and mitochondrial ceramide levels have been shown to be elevated prior to the mitochondria...

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Autors principals: Siskind, Leah J., Kolesnick, Richard N., Colombini, Marco
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246045/
https://ncbi.nlm.nih.gov/pubmed/16713754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2006.03.002
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