Screening of potential ADAMTS-4 inhibitors utilizing a collagen-model FRET substrate

The major components of the cartilage extracellular matrix are type II collagen and aggrecan. Type II collagen provides cartilage with its tensile strength, while the water-binding capacity of aggrecan provides compressibility and elasticity. Aggrecan breakdown leads to an increase in proteolytic su...

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Main Authors: Lauer-Fields, Janelle L., Spicer, Timothy P., Chase, Peter S., Cudic, Mare, Burstein, Gayle D., Nagase, Hideaki, Hodder, Peter, Fields, Gregg B.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2245870/
https://ncbi.nlm.nih.gov/pubmed/17949675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.09.014
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