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Screening of potential ADAMTS-4 inhibitors utilizing a collagen-model FRET substrate
The major components of the cartilage extracellular matrix are type II collagen and aggrecan. Type II collagen provides cartilage with its tensile strength, while the water-binding capacity of aggrecan provides compressibility and elasticity. Aggrecan breakdown leads to an increase in proteolytic su...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2245870/ https://ncbi.nlm.nih.gov/pubmed/17949675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.09.014 |
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