Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

Aberrant TGFβ signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells, are recruited into mammary carcinomas with type II TGFβ receptor gene (Tgfbr2) deletion and directly promote tumor metastasis. Gr-1+CD11b+ cells infiltrate int...

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Autors principals: Yang, Li, Huang, Jianhua, Ren, Xiubao, Gorska, Agnieszka E., Chytil, Anna, Aakre, Mary, Carbone, David P., Matrisian, Lynn M., Richmond, Ann, Lin, P. Charles, Moses, Harold L.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2245859/
https://ncbi.nlm.nih.gov/pubmed/18167337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.12.004
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