X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes

Human carbonic anhydrases (CAs) are well studied targets for the development of inhibitors for pharmaceutical applications. The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a —C...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Fisher, S. Zoë, Govindasamy, Lakshmanan, Boyle, Nicholas, Agbandje-McKenna, Mavis, Silverman, David N., Blackburn, G. Michael, McKenna, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2006
Schlagworte:
Protein Structure Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242956/
https://ncbi.nlm.nih.gov/pubmed/16820676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106020446
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge