Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling

Leukocytes from individuals with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIM(WT)) display impaired CXCR4 internalization and desensitization upon exposure to CXCL12. The resulting enhanced CXCR4-depende...

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Main Authors: Balabanian, Karl, Levoye, Angélique, Klemm, Lysiane, Lagane, Bernard, Hermine, Olivier, Harriague, Julie, Baleux, Françoise, Arenzana-Seisdedos, Fernando, Bachelerie, Françoise
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242619/
https://ncbi.nlm.nih.gov/pubmed/18274673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33187
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