Atomic-resolution crystal structure of Borrelia burgdorferi outer surface protein A via surface engineering

Outer surface protein A (OspA) from Borrelia burgdorferi has an unusual dumbbell-shaped structure in which two globular domains are connected with a “single-layer” β-sheet (SLB). The protein is highly soluble, and it has been recalcitrant to crystallization. Only OspA complexes with Fab fragments ha...

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Bibliographic Details
Main Authors: Makabe, Koki, Tereshko, Valentina, Gawlak, Grzegorz, Yan, Shude, Koide, Shohei
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242579/
https://ncbi.nlm.nih.gov/pubmed/16823038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062246706
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