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Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass

The possible conformational changes of DNA polymerase IV (Dpo4) before and after the nucleotidyl-transfer reaction are investigated at the atomic level by dynamics simulations to gain insight into the mechanism of low-fidelity polymerases and identify slow and possibly critical steps. The absence of...

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Bibliografiske detaljer
Main Authors: Wang, Yanli, Arora, Karunesh, Schlick, Tamar
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242364/
https://ncbi.nlm.nih.gov/pubmed/16322565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051726906
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