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NEGATIVE COOPERATIVITY IN REGULATORY ENZYMES

Negative cooperativity has been observed in CTP synthetase, an allosteric enzyme which contains a regulatory site. Thus, the same enzyme exhibits negative cooperativity for GTP (an effector) and glutamine (a substrate) and positive cooperativity for ATP and UTP (both substrates). In the process of t...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Levitzki, Alexander, Koshland, D. E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1969
Schlagworte:
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC223623/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5256410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.62.4.1121
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