Constitutively active STAT6 predisposes toward a lymphoproliferative disorder

Signal transducer and activator of transcription 6 (STAT6) is critical for IL-4 and IL-13 responses, and necessary for the normal development of Th2 cells. We previously generated mice that express a constitutively active STAT6 (STAT6VT) under control of the CD2 locus control region, which directs e...

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Autores principales: Kaplan, Mark H., Sehra, Sarita, Chang, Hua-Chen, O'Malley, John T., Mathur, Anubhav N., Bruns, Heather A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2007
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234780/
https://ncbi.nlm.nih.gov/pubmed/17878403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-098244
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