STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease

STAT4, a critical regulator of inflammation in vivo, can be expressed as two alternative splice forms, a full-length STAT4α, and a STAT4β isoform lacking a C-terminal transactivation domain. Each isoform is sufficient to program Th1 development through both common and distinct subsets of target gene...

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Autori principali: O’Malley, John T., Eri, Rajaraman D., Stritesky, Gretta L., Mathur, Anubhav N., Chang, Hua-Chen, HogenEsch, Harm, Srinivasan, Mythily, Kaplan, Mark H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596939/
https://ncbi.nlm.nih.gov/pubmed/18802110
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