STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease

STAT4, a critical regulator of inflammation in vivo, can be expressed as two alternative splice forms, a full-length STAT4α, and a STAT4β isoform lacking a C-terminal transactivation domain. Each isoform is sufficient to program Th1 development through both common and distinct subsets of target gene...

Full description

Saved in:
Bibliographic Details
Main Authors: O’Malley, John T., Eri, Rajaraman D., Stritesky, Gretta L., Mathur, Anubhav N., Chang, Hua-Chen, HogenEsch, Harm, Srinivasan, Mythily, Kaplan, Mark H.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596939/
https://ncbi.nlm.nih.gov/pubmed/18802110
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items