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MISMATCH REPAIR-DEPENDENT ITERATIVE EXCISION AT IRREPARABLE O(6)-METHYLGUANINE LESIONS IN HUMAN NUCLEAR EXTRACTS
The response of mammalian cells to S(N)1 DNA methylators depends on functional MutSα and MutLα. Cells deficient in either of these activities are resistant to the cytotoxic effects of this class of chemotherapeutic drug. Because killing by S(N)1 methylators has been attributed to O(6)-methylguanine...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234603/ https://ncbi.nlm.nih.gov/pubmed/16772289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M603667200 |
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