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Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations
Age is the single most important prognostic factor in the development of many cancers. The major reason for this age-dependence is thought to be the progressive accumulation of oncogenic mutations and epigenetic changes. Similarly, mutagens are thought to be carcinogenic primarily by engendering onc...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234267/ https://ncbi.nlm.nih.gov/pubmed/17980163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2007.09.001 |
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