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Challenging the axiom: Does the occurrence of oncogenic mutations truly limit cancer development with age?
A widely accepted paradigm in cancer research holds that the development of cancers is rate-limited by the occurrence of oncogenic mutations. In particular, the exponential rise in the incidence of most cancers with age is thought to reflect the time required for cells to accumulate the multiple onc...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670419/ https://ncbi.nlm.nih.gov/pubmed/22751134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.281 |
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