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REPLICATIONAL STRESS SELECTS FOR P53 MUTATION

p53 is a critical mediator of cellular responses to a variety of stresses. Given the frequency of p53 mutations in human malignancies and that disruption of p53 has been implicated in chemoresistance, understanding the factors that select for p53 disruption is important both for understanding tumor...

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Detalhes bibliográficos
Main Authors: Marusyk, Andriy, DeGregori, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394679/
https://ncbi.nlm.nih.gov/pubmed/17786047
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