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Intrinsically disordered γ-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure
The retinal phosphodiesterase (PDE6) inhibitory γ-subunit (PDEγ) plays a central role in vertebrate phototransduction through alternate interactions with the catalytic αβ-subunits of PDE6 and the α-subunit of transducin (α(t)). Detailed structural analysis of PDEγ has been hampered by its intrinsic...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234174/ https://ncbi.nlm.nih.gov/pubmed/18230733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709558105 |
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