Osteoblast expression of an engineered G(s)-coupled receptor dramatically increases bone mass

Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the parathyroid hormone receptor, can increase bone mass; however, the anabolic mechanisms are poorly understood. Here we use...

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Detalhes bibliográficos
Main Authors: Hsiao, Edward C., Boudignon, Benjamin M., Chang, Wei C., Bencsik, Margaret, Peng, Jeffrey, Nguyen, Trieu D., Manalac, Carlota, Halloran, Bernard P., Conklin, Bruce R., Nissenson, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234117/
https://ncbi.nlm.nih.gov/pubmed/18212126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707457105
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