Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-κB–dependent DNA methyltransferase activity in acute myeloid leukemia

Bortezomib reversibly inhibits 26S proteasomal degradation, interferes with NF-κB, and exhibits antitumor activity in human malignancies. Zinc finger protein Sp1 transactivates DNMT1 gene in mice and is functionally regulated through protein abundance, posttranslational modifications (ie, ubiquitina...

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Hauptverfasser: Liu, Shujun, Liu, Zhongfa, Xie, Zhiliang, Pang, Jiuxia, Yu, Jianhua, Lehmann, Esther, Huynh, Lenguyen, Vukosavljevic, Tamara, Takeki, Mitsui, Klisovic, Rebecca B., Baiocchi, Robert A., Blum, William, Porcu, Pierluigi, Garzon, Ramiro, Byrd, John C., Perrotti, Danilo, Caligiuri, Michael A., Chan, Kenneth K., Wu, Lai-Chu, Marcucci, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234064/
https://ncbi.nlm.nih.gov/pubmed/18083845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-110171
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