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Analysis of [3′,3′-d(2)]-nicotine and [3′,3′-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry

A selective and sensitive LC/MS/MS assay was developed for the quantification of d(2)-nicotine and d(2)-cotinine in plasma of current and past smokers administered d(2)-nicotine. After solid phase extraction and liquid liquid extraction, HPLC separation was achieved on a capillary hydrophilic intera...

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Detalhes bibliográficos
Main Authors: Murphy, Sharon E., Villalta, Peter, Ho, Sing-Wei, von Weymarn, Linda B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234036/
https://ncbi.nlm.nih.gov/pubmed/17644451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2007.06.018
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