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Hysteresis in the Voltage Dependence of HCN Channels: Conversion between Two Modes Affects Pacemaker Properties

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels are important for rhythmic activity in the brain and in the heart. In this study, using ionic and gating current measurements, we show that cloned spHCN channels undergo a hysteresis in their voltage dependence during normal gat...

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Detalhes bibliográficos
Main Authors: Männikkö, Roope, Pandey, Shilpi, Larsson, H. Peter, Elinder, Fredrik
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234019/
https://ncbi.nlm.nih.gov/pubmed/15710913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409130
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